Alkylation of Indoles with α,β‐Unsaturated Ketones using Alumina in Hexanes

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Friedel-Crafts alkylation of indoles with epoxides using PW12-APTES@SBA-15

H3PW12O40 (PW12) was immobilized over mesoporous alumina through the reaction of mesoporous alumina functionalized 3-aminopropyl triethoxy silane (3-APTES) and PW12. The surface properties of the functionalized nanocomposite was analyzed by a series of characterization techniques like elemental analysis, FTIR and XRD. XRD and adsorption–desorption analysis shows that the mesostructure of silica...

متن کامل

Ruthenium-catalyzed direct C3 alkylation of indoles with α,β-unsaturated ketones.

In this paper, a simple and highly efficient ruthenium-catalyzed direct C3 alkylation of indoles with various α,β-unsaturated ketones without chelation assistance has been developed. This novel C-H activation methodology exhibits a broad substrate scope such as different substituted indoles, pyrroles, and other azoles. Further synthetic applications of the alkylation products can lead to more a...

متن کامل

FeCl3-promoted alkylation of indoles by enamides.

An efficient iron-promoted alkylation of indoles with enamides has been accomplished under mild reaction conditions. The reaction proceeded with remarkable regioselectivity leading exclusively to substitution by indoles at α-position of enamides.

متن کامل

Catalytic asymmetric alkylation of ketones using organometallic reagents.

The catalytic asymmetric synthesis of tertiary alcohols by the addition of organometallic reagents to ketones is of central importance in organic chemistry. The resulting quaternary stereocentres are difficult to prepare selectively by other means despite their widespread occurrence in natural products and pharmaceuticals. Over the past few years, several seminal reports on the formation of chi...

متن کامل

Synthesis of Fused Polycyclic Indoles by Brønsted Acid-Catalyzed Intramolecular Alkylation of Indoles with Alcohols.

An efficient methodology for the synthesis of a series of new fused polyclyclic indoles has been developed by Brønsted acid-catalyzed intramolecular Friedel-Crafts reactions of properly designed indolyl alcohols.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Advanced Synthesis & Catalysis

سال: 2019

ISSN: 1615-4150,1615-4169

DOI: 10.1002/adsc.201901037